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In Ghost Squad Evolution, player is a member of Alpha Unit, or members of the “Ghost Squad”, an unofficial unit of the anti-terrorist group, Multi-Operation-Program Non-playable characters include fellow M.O.P. members consisting of the Commander, who provides radio backup and pertinent advice to the player. Along with the Bravo and Charlie Unit who assist the player in suppressing the terrorist threat.
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Players assume the role of special agents fighting their way through a haunted mansion filled with crazed zombies, chainsaw-wielding "Undeads" and other nasty creatures coming at you from the deepest, darkest corners of Dr. Curien's Mansion, with these loathsome creatures are hell-bent on destroying mankind - that is unless you destroy them first. As a special agent, your mission is to wipe out the zombie menace and stop Dr. Curien's latest successor from carrying out his evil plans.